Tumor lymphatics

被引：117

作者：

Sleeman, Jonathan ^{[1
,2
]}

Schmid, Anja ^{[2
]}

Thiele, Wilko ^{[1
,2
]}

机构：

[1] Univ Heidelberg, Med Fac Mannheim, D-68167 Mannheim, Germany

[2] Inst Genet & Toxikol, Forschungszentrum Karlsruhe, D-76021 Karlsruhe, Germany

来源：

SEMINARS IN CANCER BIOLOGY | 2009年 / 19卷 / 05期

关键词：

Metastasis; Lymphangiogenesis; Lymphatic endothelial cells; Lymph node; Tumor dissemination; VEGF-C; VEGF-D; VEGFR-3; ENDOTHELIAL-GROWTH-FACTOR; BREAST-CANCER METASTASIS; RECEPTOR TYROSINE KINASES; CELL LUNG-CANCER; NODE METASTASIS; VEGF-C; BONE-MARROW; IN-VIVO; INDUCED LYMPHANGIOGENESIS; PROGENITOR CELLS;

D O I：

10.1016/j.semcancer.2009.05.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In this article we survey more than three centuries of observation and research into tumor-associated lymphatic vessels, and their role in the metastatic spread of cancer. This historical overview documents how questions regarding tumor lymphatics have been central to concepts about the process of metastasis, and how this has subsequently influenced the clinical treatment of cancer. In turn, we show how analysis of the efficacy of these treatments has challenged long-standing notions regarding the tumor lymphatics. Starting with the discovery of VEGFR-3 and its ligands VEGF-C and VEGF-D, we also review how the rapid developments over the last 15 years in the molecular analysis of the lymphatic system and in particular lymphangiogenesis have contributed to this debate. Finally we speculate on how apparently paradoxical bodies of evidence regarding the role of tumor lymphatics in determining patterns of metastatic spread might be reconciled. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：285 / 297

页数：13

共 187 条

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[2]

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