Endothelin role in kidney acidification

被引：11

作者：

Wesson, Donald E. ^{[1
]}

机构：

[1] Texas Tech Univ, Hlth Sci Ctr, Sch Med, Div Nephrol & Hypertens, Lubbock, TX 79430 USA

来源：

SEMINARS IN NEPHROLOGY | 2006年 / 26卷 / 05期

关键词：

dietary acid; distal tubule; proximal tubule; aldosterone; sodium hydrogen exchange; H+-ATPase;

D O I：

10.1016/j.semnephrol.2006.07.006

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Endothelin is a potent vasoconstrictor that recent studies show modulates transport in kidney tubules, including that related to acidification. The data support a physiologic role for endothelin in mediating enhanced kidney tubule acidification in response to an acid challenge to systemic acid-base balance status. The data to date do not support an endothelin role in maintaining kidney tubule acidification in control, nonacid-challenged states. Endothelin also contributes to the enhanced acidification of some pathophysiologic states and might have a role in some of the untoward outcomes associated with these conditions. This reviews supports continuation of studies into the physiologic and possibly pathophysiologic role of endothelin in settings of increased tubule acidification. © 2006 Elsevier Inc. All rights reserved.

引用

页码：393 / 398

页数：6

共 86 条

[1] ROLE OF NEUTRAL ENDOPEPTIDASE IN THE METABOLISM OF ENDOTHELIN [J].

ABASSI, ZA ;

TATE, JE ;

GOLOMB, E ;

KEISER, HR .

HYPERTENSION, 1992, 20 (01) :89-95

[2] Glucocorticoids enhance acid activation of the Na+/H+ exchanger 3 (NHE3) [J].

Ambühl, PM ;

Yang, XJ ;

Peng, Y ;

Preisig, PA ;

Moe, OW ;

Alpern, RJ .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (03) :429-435

[3] Stimulation of NHE3 in OKP cells by an autocrine mechanism [J].

Amemiya, M ;

Mori, H ;

Imamura, S ;

Toyoda, A ;

Funayama, I ;

Asano, Y ;

Kusano, E ;

Tabei, K .

NEPHRON EXPERIMENTAL NEPHROLOGY, 2004, 96 (01) :23-30

[4] Endothelins stimulate aldosterone secretion from dispersed rat adrenal zona glomerulosa cells, acting through ETB receptors coupled with the phospholipase C-dependent signaling pathway [J].

Andreis, PG ;

Tortorella, C ;

Malendowicz, LK ;

Nussdorfer, GG .

PEPTIDES, 2001, 22 (01) :117-122

[5] EFFECT OF GLUCOCORTICOIDS ON RENAL CORTICAL NHE-3 AND NHE-1 MESSENGER-RNA [J].

BAUM, M ;

MOE, OW ;

GENTRY, DL ;

ALPERN, RJ .

AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 267 (03) :F437-F442

[6] INCREASED RENAL ENDOTHELIN PRODUCTION IN RATS WITH REDUCED RENAL MASS [J].

BENIGNI, A ;

PERICO, N ;

GASPARI, F ;

ZOJA, C ;

BELLIZZI, L ;

GABANELLI, M ;

REMUZZI, G .

AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (03) :F331-F339

[7] PRESENCE AND SECRETION OF ATRIAL-NATRIURETIC-PEPTIDE FROM CULTURED HUMAN AORTIC ENDOTHELIAL-CELLS [J].

BRANDT, RR ;

HEUBLEIN, DM ;

MATTINGLY, MT ;

PITTELKOW, MR ;

BURNETT, JC .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1995, 268 (02) :H921-H925

[8] SEGMENTAL ANALYSIS OF THE RENAL TUBULE IN BUFFER PRODUCTION AND NET ACID FORMATION [J].

BUERKERT, J ;

MARTIN, D ;

TRIGG, D .

AMERICAN JOURNAL OF PHYSIOLOGY, 1983, 244 (04) :F442-F454

[9] ACIDIFICATION IN MAMMALIAN CORTICAL DISTAL TUBULE [J].

CAPASSO, G ;

MALNIC, G ;

WANG, T ;

GIEBISCH, G .

KIDNEY INTERNATIONAL, 1994, 45 (06) :1543-1554

[10] Endothelin(B) receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells [J].

Chu, TS ;

Peng, Y ;

Cano, A ;

Yanagisawa, M ;

Alpern, RJ .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (06) :1454-1462

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