Preparation of polyfunctional tertiary amines via the electrophilic amination of arylmagnesium compounds using N-chloroamines

被引：19

作者：

Sinha, Pradipta ^{[1
]}

Knochel, Paul ^{[1
]}

机构：

[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany

来源：

SYNLETT | 2006年 / 19期

关键词：

electrophilic amination; polyfunctional tertiary amines; arylmagnesium compounds; halogen-magnesium exchange; N-chloroamines;

D O I：

10.1055/s-2006-951560

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Functionalized arylmagnesium compounds prepared via a halogen-magnesium exchange reaction using aryl iodides or bromides and i-PrMgCl.LiCl, react rapidly with benzyl-N-chloroamines at -45 degrees C providing polyfunctional tertiary amines in good yields. The methodology is also successfully applied to the preparation of chiral N-chloroamines with retention of chirality.

引用

页码：3304 / 3308

页数：5

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