Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus

被引:97
作者
Fortunato, Jucelia J. [1 ,2 ]
Reus, Gislaine Z. [1 ,2 ]
Kirsch, Tamires R. [1 ,2 ]
Stringari, Roberto B. [1 ,2 ]
Stertz, Laura [3 ,4 ]
Kapczinski, Flavio [3 ,4 ]
Pinto, Joel P. [5 ,6 ]
Hallak, Jaime E. [5 ,6 ]
Zuardi, Antonio W. [5 ,6 ]
Crippa, Jose A. [5 ,6 ]
Quevedo, Joao [1 ,2 ]
机构
[1] Univ Extremo Sul Catarinense, Lab Neurociencias, BR-88806000 Criciuma, SC, Brazil
[2] Univ Extremo Sul Catarinense, Unidade Acad Ciencias Saude, Programa Posgrad Ciencias Saude, Inst Nacl Ciencia & Tecnol Translac Med, BR-88806000 Criciuma, SC, Brazil
[3] Hosp Clin Porto Alegre, Lab Psiquiatria Mol, BR-90035003 Porto Alegre, RS, Brazil
[4] Hosp Clin Porto Alegre, Ctr Pesquisas, Inst Nacl Ciencia & Tecnol Translac Med, BR-90035003 Porto Alegre, RS, Brazil
[5] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Neurociencias & Ciencias Comportamento, BR-14049900 Ribeirao Preto, SP, Brazil
[6] Univ Sao Paulo, Fac Med Ribeirao Preto, Inst Ciencia & Tecnol Translac Med, BR-14049900 Ribeirao Preto, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
BDNF; Depression; Forced swimming test; Harmine; Imipramine; FORCED-SWIMMING TEST; NEUROTROPHIC FACTOR; ANIMAL-MODEL; DEPRESSION; BINDING; INHIBITION; EXPRESSION; IMMOBILITY; ALKALOIDS;
D O I
10.1016/j.pnpbp.2009.07.021
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Harmine is a beta-carboline alkaloid that inhibits monoamine reuptake systems. Findings point to an antidepressant effect of the compounds that increases the levels of monoamines after monoamine oxidase inhibition. The present study aims to compare the behavioral effects and the BDNF hippocampus levels of acute administration of harmine and imipramine in rats. To this aim, rats were acutely treated with harmine (5, 10 and 15 mg/kg) and imipramine (10, 20 and 30 mg/kg) and animal behavior was assessed in the forced swimming and open-field tests. Afterwards, hippocampal BDNF protein levels were assessed in imipramine- and harmine-treated rats by ELISA-sandwich assay. We observed that harmine at doses of 10 and 15 mg/kg, and imipramine at 20 and 30 mg/kg reduced immobility time, and increased both climbing and swimming time of rats compared to saline group, without affecting locomotor activity. Acute administration of harmine at the higher dose, but not imipramine, increased BDNF protein levels in the rat hippocampus. Finally, these findings further support the hypothesis that harmine could be a new pharmacological target for the treatment of mood disorders. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:1425 / 1430
页数:6
相关论文
共 42 条
[1]   Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities [J].
Astulla, Adil ;
Zaima, Kazumasa ;
Matsuno, Yosuke ;
Hirasawa, Yusuke ;
Ekasari, Wiwied ;
Widyawaruyanti, Aty ;
Zaini, Noor Cholies ;
Morita, Hiroshi .
JOURNAL OF NATURAL MEDICINES, 2008, 62 (04) :470-472
[2]   Ethopharmacology of imipramine in the forced-swimming test: gender differences [J].
Barros, HMT ;
Ferigolo, M .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1998, 23 (02) :279-286
[3]   Nonpeptidic δ-opioid receptor agonists reduce immobility in the forced swim assay in rats [J].
Broom, DC ;
Jutkiewicz, EM ;
Folk, JE ;
Traynor, JR ;
Rice, KC ;
Woods, JH .
NEUROPSYCHOPHARMACOLOGY, 2002, 26 (06) :744-755
[4]   Role of neurotrophic factors in depression [J].
Castren, Eero ;
Voikar, Vootele ;
Rantamaki, Tomi .
CURRENT OPINION IN PHARMACOLOGY, 2007, 7 (01) :18-21
[5]  
Charney DS, 1998, J CLIN PSYCHIAT, V59, P11
[6]   The impact of treatment-resistant depression on health care utilization and costs [J].
Crown, WH ;
Finkelstein, S ;
Berndt, ER ;
Ling, D ;
Poret, AW ;
Rush, AJ ;
Russell, JM .
JOURNAL OF CLINICAL PSYCHIATRY, 2002, 63 (11) :963-971
[7]   Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment [J].
De Foubert, G ;
Carney, SL ;
Robinson, CS ;
Destexhe, EJ ;
Tomlinson, R ;
Hicks, CA ;
Murray, TK ;
Gaillard, JP ;
Deville, C ;
Xhenseval, V ;
Thomas, CE ;
O'Neill, MJ ;
Zetterström, TSC .
NEUROSCIENCE, 2004, 128 (03) :597-604
[8]   ACTIVE BEHAVIORS IN THE RAT FORCED SWIMMING TEST DIFFERENTIALLY PRODUCED BY SEROTONERGIC AND NORADRENERGIC ANTIDEPRESSANTS [J].
DETKE, MJ ;
RICKELS, M ;
LUCKI, I .
PSYCHOPHARMACOLOGY, 1995, 121 (01) :66-72
[9]   A neurotrophic model for stress-related mood disorders [J].
Duman, Ronald S. ;
Monteggia, Lisa M. .
BIOLOGICAL PSYCHIATRY, 2006, 59 (12) :1116-1127
[10]   Antidepressant-like effect of harmane and other β-carbolines in the mouse forced swim test [J].
Farzin, Davood ;
Mansouri, Nazanin .
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2006, 16 (05) :324-328