Catch me if you can! Oxidative protein trapping in the intermembrane space of mitochondria

被引：76

作者：

Herrmann, Johannes M. ^{[1
]}

Koehl, Roman ^{[1
]}

机构：

[1] Univ Kaiserslautern, Dept Cell Biol, D-67663 Kaiserslautern, Germany

来源：

JOURNAL OF CELL BIOLOGY | 2007年 / 176卷 / 05期

关键词：

D O I：

10.1083/jcb.200611060

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The intermembrane space (IMS) of mitochondria, the compartment that phylogenetically originated from the periplasm of bacteria, contains machinery to catalyze the oxidative folding of proteins (Mesecke, N., N. Terziyska, C. Kozany, F. Baumann, W. Neupert, K. Hell, and J. M. Herrmann. 2005. Cell. 121: 1059-1069; Rissler, M., N. Wiedemann, S. Pfannschmidt, K. Gabriel, B. Guiard, N. Pfanner, and A. Chacinska. 2005. J. Mol. Biol. 353: 485-492; Tokatlidis, K. 2005. Cell. 121: 965-96). This machinery introduces disufide bonds into newly imported precursor proteins, thereby locking them in a folded conformation. Because folded proteins cannot traverse the translocase of the outer membrane, this stably traps the proteins in the mitochondria. The principle of protein oxidation in the IMS presumably has been conserved from the bacterial periplasm and has been adapted during evolution to drive the vectorial translocation of proteins from the cytosol into the mitochondria.

引用

页码：559 / 563

页数：5

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