Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision?

被引：86

作者：

Lavieu, Gregory

Scarlatti, Francesca

Sala, Giusy

Levade, Thierry

Ghidoni, Riccardo

Botti, Joelle

Codogno, Patrice

机构：

[1] Inst Andre Lwoff, INSERM, U504, Villejuif, France

[2] San Paolo Med Sch, Lab Biochem & Mol Biol, Milan, Italy

[3] Ctr Hosp Univ Rangueil, INSERM, U466, Inst Louis Bugnard, Toulouse, France

[4] Univ Paris Sud, INSERM, U576, Fac Pharm, Chatenay Malabry, France

来源：

AUTOPHAGY | 2007年 / 3卷 / 01期

关键词：

cell death; sphingosine; 1-phosphate; sphingosine kinase; ceramide; cancer; sphingolipids;

D O I：

10.4161/auto.3416

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Sphingolipids are major constituents of biological membrane and some of them behave as second messengers involved in the cell fate decision. Ceramide and sphingosine 1-phosphate (S1P) constitute a rheostat system in which ceramide promotes cell death and S1P increases cell survival. We have shown that both sphingolipids are able to trigger autophagy with opposing outcomes on cell survival. Here we discuss and speculate on the diverging functions of the autophagic pathways induced by ceramide and SIP, respectively.

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页码：45 / 47

页数：3

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