Ventricular Geometry From Non-contrast Non-ECG-gated CT Scans: An Imaging Marker of Cardiopulmonary Disease in Smokers

被引：18

作者：

Rahaghi, Farbod N. ^{[1
]}

Vegas-Sanchez-Ferrero, Gonzalo ^{[2
,3
,4
]}

Minhas, Jasleen K. ^{[1
]}

Come, Carolyn E. ^{[1
]}

De La Bruere, Isaac ^{[1
]}

Wells, James M. ^{[5
]}

Gonzalez, German ^{[2
]}

Bhatt, Surya P. ^{[5
]}

Fenster, Brett E. ^{[6
]}

Diaz, Alejandro A. ^{[1
]}

Kohli, Puja ^{[7
]}

Ross, James C. ^{[2
]}

Lynch, David A. ^{[8
]}

Dransfield, Mark T. ^{[5
]}

Bowler, Russel P. ^{[9
]}

Ledesma-Carbayo, Maria J. ^{[3
,4
]}

Estepar, Raul San Jose ^{[2
]}

Washko, George R. ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Dept Med, Pulm & Crit Care Div, 75 Francis St,PBB CA 3, Boston, MA 02115 USA

[2] Harvard Sch Med, Dept Radiol, Boston, MA USA

[3] Univ Politecn Madrid, Biomed Image Technol, Madrid, Spain

[4] CIBER BBN, Madrid, Spain

[5] Univ Alabama Birmingham, Div Pulm Allergy & Crit Care Med, Birmingham, AL USA

[6] Natl Jewish Hlth, Dept Med, Div Cardiol, Denver, CO USA

[7] Massachusetts Gen Hosp, Dept Med, Pulm & Crit Care Div, Boston, MA 02114 USA

[8] Natl Jewish Hlth, Dept Radiol, Denver, CO USA

[9] Natl Jewish Hlth, Dept Med, Div Pulm Crit Care & Sleep Med, Denver, CO USA

来源：

ACADEMIC RADIOLOGY | 2017年 / 24卷 / 05期

关键词：

Non-ECG-gated; non-contrast; computed tomography; ventricular volume; ventricular geometry; heart; cardiac; smokers; COPD; COPDGene; congestive heart failure; echocardiography; pulmonary hypertension; right heart failure; left heart failure; HEART; SEGMENTATION; HYPERTENSION; MORPHOLOGY; CAVITIES; COPD;

D O I：

10.1016/j.acra.2016.12.007

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

Rationale and Objectives: Imaging-based assessment of cardiovascular structure and function provides clinically relevant information in smokers. Non-cardiac-gated thoracic computed tomographic (CT) scanning is increasingly leveraged for clinical care and lung Cancer screening. We sought to determine if more comprehensive measures of ventricular geometry could be obtained from CT using an atlas-based surface model of the heart. Materials and Methods: Subcohorts of 24 subjects with cardiac magnetic resonance imaging (MRI) and 262 subjects with echocardiography were identified from COPDGene, a longitudinal observational study of smokers. A surface model of the heart was manually initialized, and then automatically optimized to fit the epicardium for each CT. Estimates of right and left ventricular (RV and LV) volume and free wall curvature were then calculated and compared to structural and functional metrics obtained from MRI and echocardiograms. Results: CT measures of RV dimension and curvature correlated with similar measures obtained using MRI. RV and LV volume obtained from CT inversely correlated with echocardiogram-based estimates of RV systolic pressure using tricuspid regurgitation jet velocity and LV ejection fraction respectively. Patients with evidence of RV or LV dysfunction on echocardiogram had larger RV and LV dimensions on CT. Logistic regression models based on demographics and ventricular measures from CT had an area under the curve of >0.7 for the prediction of elevated right ventricular systolic pressure and ventricular failure. Conclusions: These data suggest that non-cardiac-gated, non-contrast-enhanced thoracic CT scanning may provide insight into cardiac structure and function in smokers. (C) 2017 Published by Elsevier Inc. on behalf of The Association of University Radiologists.

引用

页码：594 / 602

页数：9

共 22 条

[1]

Coronary artery and thoracic calcium on noncontrast thoracic CT scans: Comparison of ungated and gated examinations in patients from the COPD Gene cohort [J].