Voltage-gated potassium channels in human ductus arteriosus

被引：78

作者：

Michelakis, E

Rebeyka, I

Bateson, J

Olley, P

Puttagunta, L

Archer, S ^{[1
]}

机构：

[1] Univ Alberta, Dept Med, Edmonton, AB T6G 2B7, Canada

[2] Univ Alberta, Dept Cardiothorac Surg, Edmonton, AB T6G 2B7, Canada

[3] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2B7, Canada

[4] Univ Alberta, Dept Pathol, Edmonton, AB T6G 2B7, Canada

来源：

LANCET | 2000年 / 356卷 / 9224期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0140-6736(00)02452-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied tone in the human ductus arteriosus and show that the constriction to oxygen is due to inhibition of voltage-gated potassium channels and, in the acute phase, is independent of endothelin-1.

引用

页码：134 / 137

页数：4

共 4 条

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[3] Endothelin-receptor blockade does not alter closure of the ductus arteriosus [J].

Fineman, JR ;

Takahashi, Y ;

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AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1998, 275 (05) :H1620-H1626

[4] Oxygen-induced constriction of rabbit ductus arteriosus occurs via inhibition of a 4-aminopyridine-, voltage-sensitive potassium channel [J].

TristaniFirouzi, M ;

Reeve, HL ;

Tolarova, S ;

Weir, EK ;

Archer, SL .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (09) :1959-1965

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