Cerebrovascular responses to pathophysiological insult in diabetic rats

被引：13

作者：

Fouyas, IP ^{[1
]}

Kelly, PAT ^{[1
]}

Ritchie, IM ^{[1
]}

Lammie, GA ^{[1
]}

Whittle, IR ^{[1
]}

机构：

[1] Univ Edinburgh, Western Gen Hosp, Dept Clin Neurosci, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2003年 / 10卷 / 01期

关键词：

intracerebral haemorrhage; local cerebral blood flow; blood-brain barrier; ischaemic penumbra; oligaemia; diabetes;

D O I：

10.1016/S0967-5868(02)00247-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Diabetes mellitus is associated with altered cerebrovascular responsiveness and this could contribute to the pathology of stroke in diabetic patients. In these studies, we used a model of haemorrhagic stroke (intrastriatal injection of 50 pi blood) to examine subacute perilesional perfusion and blood-brain harder (BBB) integrity in spontaneously diabetic rats. Volumes of striatal oligaemia (blood flow < 35ml 100 g(-1) min(-1)) were significantly increased (>300%) in diabetic rats with intrastriatal blood, compared to either non-diabetic rats with blood or control diabetic rats with striatal injection of silicon oil. However, the increase in BBB permeability was both qualitatively and quantitatively similar in diabetic and control rats. Poorer outcomes following haemorrhagic stroke in diabetic patients may thus result from dysfunctional cerebrovascular control, and particulady decreased dilatatory reserve. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：88 / 91

页数：4

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