Synthesis of 4-amino-3,4-dihydro-2(1H)-quinolinones via beta-lactam intermediates on the solid-phase

被引：52

作者：

Pei, YZ ^{[1
]}

Houghten, RA ^{[1
]}

Kiely, JS ^{[1
]}

机构：

[1] HOUGHTEN PHARMACEUT INC,SAN DIEGO,CA 92121

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(97)00655-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 3,4-dihydro-2(1H)-quinolinones has been accomplished through me rearrangement of beta-lactam intermediates on the solid-phase. The beta-lactam intermediates were constructed through [2+2] cycloadditions between ketenes and imines on the solid-phase. A library of 4,140 dihydroquinolinones has been produced using this synthetic process. (C) 1997 Elsevier Science Ltd.

引用

页码：3349 / 3352

页数：4

共 19 条

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