High-mobility group box 1 and cancer

被引:445
作者
Tang, Daolin [1 ]
Kang, Rui [1 ]
Zeh, Herbert J., III [1 ]
Lotze, Michael T. [1 ]
机构
[1] Univ Pittsburgh, G27A Hillman Canc Ctr, Inst Canc, DAMP Lab,Dept Surg, Pittsburgh, PA 15213 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2010年 / 1799卷 / 1-2期
关键词
HMGB1; Damage associated molecular pattern molecule [DAMP; Autophagy; Cancer; Angiogenesis; Receptor for advanced glycation endproducts [RAGE; TLR2; TLR4; CD24; TLR9; Hallmarks of cancer; Field effect; Inflammation; GLYCATION END-PRODUCTS; SQUAMOUS-CELL CARCINOMA; MOLECULAR-PATTERN MOLECULES; CHROMATIN PROTEIN HMGB1; CISPLATIN-MODIFIED DNA; NUCLEAR FACTOR HMGB1; GROUP-B PROTEINS; BREAST-CANCER; ETHYL PYRUVATE; ESTROGEN-RECEPTOR;
D O I
10.1016/j.bbagrm.2009.11.014
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
High-mobility group box 1 protein (HMGB1), a chromatin associated nuclear protein and extracellular damage associated molecular pattern molecule (DAMP), is an evolutionarily ancient and critical regulator of cell death and survival. Overexpression of HMGB1 is associated with each of the hallmarks of cancer including unlimited replicative potential, ability to develop blood vessels (angiogenesis), evasion of programmed cell death (apoptosis), self-sufficiency in growth signals, insensitivity to inhibitors of growth, inflammation, tissue invasion and metastasis. Our studies and those Of Our Colleagues Suggest that HMGB1 is central to cancer (abnormal Wound healing) and many of the findings in normal Wound healing as well. Here, we focus on the role of HMGB1 in cancer, the mechanisms by which it contributes to carcinogenesis, and therapeutic strategies based on targeting HMGB1. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:131 / 140
页数:10
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