Upper motor neuron lesions in stroke patients do not induce anterograde transneuronal degeneration in spinal anterior horn cells

被引:42
作者
Terao, S
Li, M
Hashizume, Y
Osano, Y
Mitsuma, T
Sobue, G
机构
[1] AICHI MED UNIV, INST MED SCI & AGING, NAGAKUTE, AICHI 48011, JAPAN
[2] NAGOYA UNIV, SCH MED, DEPT NEUROL, NAGOYA, AICHI 466, JAPAN
关键词
hemiplegia; spinal anterior horn cell; transneuronal degeneration; cerebrovascular disorders; corticospinal tract;
D O I
10.1161/01.STR.28.12.2553
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose To determine whether upper motor neuron lesions in stroke can cause transneuronal degeneration of lower motor neurons, we assessed spinal anterior horn cells in patients dying with poststroke hemiplegia. Methods Subjects were four stroke patients with severe left hemiplegia and four age-matched control subjects who died of nonneurological disease. After histological processing and staining, cytoarchitectonic assessment was made of all neurons in the ventral horns of the 4th lumbar segment of the spinal cord according to cell diameter and topography. Results In the four stroke patients, no differences were seen in anterior horn cell populations or diameter and size distribution patterns between affected and unaffected sides or between these patients and the control subjects. Conclusions The present quantitative analysis provides no evidence of anterograde transneuronal degeneration of lower motor neurons after upper motor neuron damage in stroke patients.
引用
收藏
页码:2553 / 2556
页数:4
相关论文
共 38 条
[1]   ELECTROPHYSIOLOGICAL STUDY OF HEMIPLEGIA - MOTOR-NERVE CONDUCTION-VELOCITY, BRACHIAL-PLEXUS LATENCY, AND ELECTROMYOGRAPHY [J].
CHOKROVERTY, S ;
MEDINA, J .
ARCHIVES OF NEUROLOGY, 1978, 35 (06) :360-363
[2]   ELECTRON-MICROSCOPIC OBSERVATIONS ON THE SYNAPTIC CONTACTS OF GROUP IA MUSCLE-SPINDLE AFFERENTS IN THE CAT LUMBOSACRAL SPINAL-CORD [J].
CONRADI, S ;
CULLHEIM, S ;
GOLLVIK, L ;
KELLERTH, JO .
BRAIN RESEARCH, 1983, 265 (01) :31-39
[3]  
DAVIDOFF RA, 1990, NEUROLOGY, V40, P332
[4]  
FUJISAWA K, 1979, BRAIN NERVE, V31, P233
[5]  
GHETTI B, 1975, ADV NEUROL, V12, P401
[6]  
GOLDKAMP OTTO, 1967, ARCH PHYS MED REHABIL, V48, P59
[7]  
Ikuta F, 1982, ADV NEUROL SCI, V26, P710
[8]   CORTICOFUGAL PROJECTIONS TO THE MOTOR NUCLEI OF THE BRAIN-STEM AND SPINAL-CORD IN HUMANS [J].
IWATSUBO, T ;
KUZUHARA, S ;
KANEMITSU, A ;
SHIMADA, H ;
TOYOKURA, Y .
NEUROLOGY, 1990, 40 (02) :309-312
[9]   QUANTITATIVE STUDY ON NEURONS OF CERVICAL SPINAL-CORD IN CEREBRAL HEMISPHERECTOMY [J].
KANEMITSU, A ;
IKUTA, F .
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 1977, 53 (04) :189-193
[10]  
KONDO A, 1987, CLIN NEUROPATHOL, V6, P250