Polymorphism of the tumor necrosis factor α gene in patients with infiltrative tuberculosis from the Bashkortostan populations

被引：12

作者：

Bikmaeva, AR ^{[1
]}

Sibiryak, SV

Valiakhmetova, DK

Khusnutdinova, EK

机构：

[1] Russian Acad Sci, Ufa Res Ctr, Inst Biochem & Genet, Ufa 450054, Russia

[2] All Russia Ctr Eye & Plast Surg, Ufa 450054, Russia

来源：

MOLECULAR BIOLOGY | 2002年 / 36卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

pulmonary tuberculosis; DNA polymorphism; tumor necrosis factor alpha;

D O I：

10.1023/A:1020659027135

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The polymorphism at position -308 of the TNF-alpha gene promoter was analyzed in three ethnic groups and in patients with infiltrative pulmonary tuberculosis from Bashkortostan. No interethnic difference in allele or genotype frequency distribution was observed. The frequency of allele TNF2 in tuberculosis patients was significantly higher than in controls (chi(2) = 11.69, p = 0.001), suggesting association of this allele with higher risk of pulmonary tuberculosis or with markedly disturbed immune response.

引用

页码：631 / 633

页数：3

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