Integrin cytoplasmic domains as connectors to the cell's signal transduction apparatus

被引:49
作者
LaFlamme, SE
Homan, SM
Bodeau, AL
Mastrangelo, AM
机构
关键词
integrin; signal transduction; cytoplasmic domain;
D O I
10.1016/S0945-053X(97)90003-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Integrins mediate the bidirectional transfer of signals across the plasma membrane. Integrin cytoplasmic domains provide one pathway linking integrin engagement with the cell's signal transduction apparatus. Recent structure-function studies have defined regions of beta cytoplasmic domains required for integrin function and have identified distinct roles for individual alpha cytoplasmic domains in regulating cell behavior. Newly identified proteins that bind to integrin alpha and beta cytoplasmic domains have provided new insights and new questions into the mechanisms involved in integrin signaling.
引用
收藏
页码:153 / 163
页数:11
相关论文
共 60 条
  • [1] AKIYAMA SK, 1994, J BIOL CHEM, V269, P15961
  • [2] Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins)
    Berditchevski, F
    Zutter, MM
    Hemler, ME
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1996, 7 (02) : 193 - 207
  • [3] Inducible tyrosine phosphorylation of the beta(3) integrin requires the alpha(v) integrin cytoplasmic tail
    Blystone, SD
    Lindberg, FP
    Williams, MP
    McHugh, KP
    Brown, EJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (49) : 31458 - 31462
  • [4] The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta 4 integrin subunit
    Borradori, L
    Koch, PJ
    Niessen, CM
    Erkeland, S
    vanLeusden, MR
    Sonnenberg, A
    [J]. JOURNAL OF CELL BIOLOGY, 1997, 136 (06) : 1333 - 1347
  • [5] LIGAND-DEPENDENT AND LIGAND-INDEPENDENT INTEGRIN FOCAL CONTACT LOCALIZATION - THE ROLE OF THE ALPHA-CHAIN CYTOPLASMIC DOMAIN
    BRIESEWITZ, R
    KERN, A
    MARCANTONIO, EE
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1993, 4 (06) : 593 - 604
  • [6] Focal adhesions, contractility, and signaling
    Burridge, K
    ChrzanowskaWodnicka, M
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1996, 12 : 463 - 518
  • [7] DISTINCT CELLULAR FUNCTIONS MEDIATED BY DIFFERENT VLA INTEGRIN ALPHA-SUBUNIT CYTOPLASMIC DOMAINS
    CHAN, BM
    KASSNER, PD
    SCHIRO, JA
    BYERS, HR
    KUPPER, TS
    HEMLER, ME
    [J]. CELL, 1992, 68 (06) : 1051 - 1060
  • [8] INTERACTION OF FOCAL ADHESION KINASE WITH CYTOSKELETAL PROTEIN TALIN
    CHEN, HC
    APPEDDU, PA
    PARSONS, JT
    HILDEBRAND, JD
    SCHALLER, MD
    GUAN, JL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (28) : 16995 - 16999
  • [9] INTEGRINS AND SIGNAL-TRANSDUCTION PATHWAYS - THE ROAD TAKEN
    CLARK, EA
    BRUGGE, JS
    [J]. SCIENCE, 1995, 268 (5208) : 233 - 239
  • [10] Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion
    Coppolino, MG
    Woodside, MJ
    Demaurex, N
    Grinstein, S
    StArnaud, R
    Dedhar, S
    [J]. NATURE, 1997, 386 (6627) : 843 - 847