Insulin:: does it induce follicular arrest in the rat ovary?

被引：8

作者：

Kuscu, NK ^{[1
]}

Koyuncu, F ^{[1
]}

Özbilgin, K ^{[1
]}

Inan, S ^{[1
]}

Tuglu, I ^{[1
]}

Karaer, Ö ^{[1
]}

机构：

[1] Celal Bayar Univ, Sch Med, Dept Obstet & Gynecol, TR-45020 Manisa, Turkey

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 2002年 / 16卷 / 05期

关键词：

polycystic ovary syndrome; insulin; rat;

D O I：

10.1080/713603120

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The goal of this study was to investigate histological changes of the rat ovary treated with either insulin or insulin plus human chorionic gonadotropin (hCG). The study was conducted in Celal Bayar University, School of Medicine, Animal Research Laboratory. Eighteen adult female Wistar rats were divided into three groups to receive saline, or insulin, or insulin plus hCG for 4 weeks. At the end of treatment the rats were sacrificed and the ovaries were evaluated with hematoxylin and eosin. There was no abnormal change in. rats treated with saline. A thickened capsule, stromal hypertrophy and stromal cell hyperplasia, and no developing follicles, were observed in the insulin-only group. A thin capsule, developing follicles and corpora lutea, and normal theca cells and stroma were observed in the insulin-plus-hCG group. We conclude that insulin may lead to histological changes similar to stromal hyperthecosis and polycystic ovary syndrome, and may be one of the factors causing follicular arrest.

引用

页码：361 / 364

页数：4

共 12 条

[1] INSULIN ENHANCEMENT OF LUTEINIZING-HORMONE AND FOLLICLE-STIMULATING-HORMONE RELEASE BY CULTURED PITUITARY-CELLS [J].

ADASHI, EY ;

HSUEH, AJW ;

YEN, SSC .

ENDOCRINOLOGY, 1981, 108 (04) :1441-1449

[2] INSULIN STIMULATES ANDROGEN ACCUMULATION IN INCUBATIONS OF OVARIAN STROMA OBTAINED FROM WOMEN WITH HYPERANDROGENISM [J].

BARBIERI, RL ;

MAKRIS, A ;

RANDALL, RW ;

DANIELS, G ;

KISTNER, RW ;

RYAN, KJ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 62 (05) :904-910

[3] INSULIN RESISTANCE IN NON-OBESE PATIENTS WITH POLYCYSTIC OVARIAN DISEASE [J].

CHANG, RJ ;

NAKAMURA, RM ;

JUDD, HL ;

KAPLAN, SA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1983, 57 (02) :356-359

[4] CELLULAR MECHANISMS OF INSULIN RESISTANCE IN POLYCYSTIC OVARIAN SYNDROME [J].

CIARALDI, TP ;

ELROEIY, A ;

MADAR, Z ;

REICHART, D ;

OLEFSKY, JM ;

YEN, SSC .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1992, 75 (02) :577-583

[5] Activin stimulates proliferation of rat ovarian thecal-interstitial cells [J].

Duleba, AJ ;

Pehlivan, T ;

Carbone, R ;

Spaczynski, RZ .

BIOLOGY OF REPRODUCTION, 2001, 65 (03) :704-709

[6] EXCESSIVE INSULIN-RECEPTOR SERINE PHOSPHORYLATION IN CULTURED FIBROBLASTS AND IN SKELETAL-MUSCLE - A POTENTIAL MECHANISM FOR INSULIN-RESISTANCE IN THE POLYCYSTIC-OVARY-SYNDROME [J].

DUNAIF, A ;

XIA, JR ;

BOOK, CB ;

SCHENKER, E ;

TANG, ZC .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (02) :801-810

[7]

DUNAIF A, 1992, ENDOCRINOLOGIST, V2, P248

[8] Insulin infusion amplifies 17 alpha-hydroxycorticosteroid intermediates response to adrenocorticotropin in hyperandrogenic women: Apparent relative impairment of 17,20-lyase activity [J].

Moghetti, P ;

Castello, R ;

Negri, C ;

Tosi, F ;

Spiazzi, GG ;

Brun, E ;

Balducci, R ;

Toscano, V ;

Muggeo, M .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (03) :881-886

[9] SUPPRESSION OF SERUM-INSULIN BY DIAZOXIDE REDUCES SERUM TESTOSTERONE LEVELS IN OBESE WOMEN WITH POLYCYSTIC OVARY SYNDROME [J].

NESTLER, JE ;

BARLASCINI, CO ;

MATT, DW ;

STEINGOLD, KA ;

PLYMATE, SR ;

CLORE, JN ;

BLACKARD, WG .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 68 (06) :1027-1032

[10] HYPERINSULINEMIA AND HUMAN CHORIONIC-GONADOTROPIN SYNERGISTICALLY PROMOTE THE GROWTH OF OVARIAN FOLLICULAR CYSTS IN RATS [J].

PORETSKY, L ;

CLEMONS, J ;

BOGOVICH, K .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1992, 41 (08) :903-910

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