Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells

被引：11

作者：

Hayashi, S

Sugiyama, T

Yachi, A

Yokota, K

Hirai, Y

Oguma, K

Fujii, N

机构：

[1] Department of Microbiology, School of Medicine, Sapporo Medical University, Sapporo 060, South 1

[2] Department of Laboratory Diagnosis, School of Medicine, Sapporo Medical University, Sapporo 060, South 1

[3] Sapporo Medical University, Sapporo

[4] Department of Bacteriology, Okayama University Medical School, Okayama

来源：

JOURNAL OF GASTROENTEROLOGY | 1997年 / 32卷 / 05期

关键词：

ecabet sodium; Helicobacter pylori; gastric epithelial cells; adhesion;

D O I：

10.1007/BF02934107

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Helicobacter pylori is a major etiological agent in gastroduodenal disorders, with the adhesion of H. pylori to gastric epithelial cells being the initial step of H. pylori infection. Inhibition of H. pylori adhesion is thus a therapeutic target in preventing H. pylori infection. We evaluated the effect of ecabet sodium, an antiulcer agent, on H. pylori adhesion to gastric epithelial cells, using our previously established enzyme-linked immunosorbent assay. The adhesion of H. pylori was significantly inhibited by ecabet sodium in a dose dependent manner. Our studies suggest that ecabet sodium inhibits the adhesion of H. pylori to gastric epithelial cells.

引用

页码：593 / 597

页数：5

共 12 条

[1]

ASADA S, 1991, Gastroenterology, V100, pA27

[2]

FORMAN D, 1993, LANCET, V341, P1359

[3] COMBINATION THERAPIES WITH A PROTON PUMP INHIBITOR FOR HELICOBACTER PYLORI-INFECTED GASTRIC-ULCER PATIENTS [J].