Influence of Dopaminergically Mediated Reward on Somatosensory Decision-Making

被引:81
作者
Pleger, Burkhard [1 ,2 ]
Ruff, Christian C. [1 ,3 ,4 ]
Blankenburg, Felix [1 ,3 ,5 ,6 ]
Kloeppel, Stefan [1 ,7 ]
Driver, Jon [1 ,3 ]
Dolan, Raymond J. [1 ]
机构
[1] UCL, Wellcome Trust Ctr Neuroimaging, London, England
[2] Max Planck Inst Human Cognit & Brain Sci, Dept Cognit Neurol, Leipzig, Germany
[3] UCL, Inst Cognit Neurosci, London, England
[4] Univ Zurich, Inst Empir Res Econ, SNS, Lab Social & Neural Syst Res, CH-8006 Zurich, Switzerland
[5] Charite, Dept Neurol, Berlin, Germany
[6] Charite, Bernstein Ctr Computat Neurosci, Berlin, Germany
[7] Univ Freiburg, Dept Psychiat & Psychotherapy, Freiburg, Germany
来源
PLOS BIOLOGY | 2009年 / 7卷 / 07期
基金
英国医学研究理事会; 英国惠康基金;
关键词
REACTION-TIME-TASK; ATTENTIONAL PERFORMANCE; PREFRONTAL CORTEX; PARIETAL CORTEX; ORBITOFRONTAL CORTEX; PERCEPTUAL DECISION; PREDICTION ERRORS; NEURAL RESPONSES; WORKING-MEMORY; BRAIN ACTIVITY;
D O I
10.1371/journal.pbio.1000164
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Reward-related dopaminergic influences on learning and overt behaviour are well established, but any influence on sensory decision-making is largely unknown. We used functional magnetic resonance imaging ( fMRI) while participants judged electric somatosensory stimuli on one hand or other, before being rewarded for correct performance at trial end via a visual signal, at one of four anticipated financial levels. Prior to the procedure, participants received either placebo (saline), a dopamine agonist (levodopa), or an antagonist (haloperidol). Principal findings: higher anticipated reward improved tactile decisions. Visually signalled reward reactivated primary somatosensory cortex for the judged hand, more strongly for higher reward. After receiving a higher reward on one trial, somatosensory activations and decisions were enhanced on the next trial. These behavioural and neural effects were all enhanced by levodopa and attenuated by haloperidol, indicating dopaminergic dependency. Dopaminergic reward-related influences extend even to early somatosensory cortex and sensory decision-making.
引用
收藏
页数:10
相关论文
共 62 条
  • [1] Modeling geometric deformations in EPI time series
    Andersson, JLR
    Hutton, C
    Ashburner, J
    Turner, R
    Friston, K
    [J]. NEUROIMAGE, 2001, 13 (05) : 903 - 919
  • [2] How does spatial extent of fMRI datasets affect independent component analysis decomposition?
    Aragri, Adriana
    Scarabino, Tommaso
    Seifritz, Erich
    Comani, Silvia
    Cirillo, Sossio
    Tedeschi, Gioacchino
    Esposito, Fabrizio
    Di Salle, Francesco
    [J]. HUMAN BRAIN MAPPING, 2006, 27 (09) : 736 - 746
  • [3] Space, time and dopamine
    Arbuthnott, Gordon W.
    Wickens, Jeff
    [J]. TRENDS IN NEUROSCIENCES, 2007, 30 (02) : 62 - 69
  • [4] Dopaminergic effects on electrophysiological and functional MRI measures of human cortical stimulus-response power laws
    Arthurs, OJ
    Stephenson, CME
    Rice, K
    Lupson, V
    Spiegelhalter, DJ
    Boniface, SJ
    Bullmore, ET
    [J]. NEUROIMAGE, 2004, 21 (02) : 540 - 546
  • [5] Predictability modulates human brain response to reward
    Berns, GS
    McClure, SM
    Pagnoni, G
    Montague, PR
    [J]. JOURNAL OF NEUROSCIENCE, 2001, 21 (08) : 2793 - 2798
  • [6] Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion
    Blood, AJ
    Zatorre, RJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (20) : 11818 - 11823
  • [7] Functional imaging of neural responses to expectancy and experience of monetary gains and losses
    Breiter, HC
    Aharon, I
    Kahneman, D
    Dale, A
    Shizgal, P
    [J]. NEURON, 2001, 30 (02) : 619 - 639
  • [8] Dopamine-mediated regulation of corticostriatal synaptic plasticity
    Calabresi, Paolo
    Picconi, Barbara
    Tozzi, Alessandro
    Di Filippo, Massimiliano
    [J]. TRENDS IN NEUROSCIENCES, 2007, 30 (05) : 211 - 219
  • [9] The computational neurobiology of learning and reward
    Daw, ND
    Doya, K
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 2006, 16 (02) : 199 - 204
  • [10] The role of the striatum in aversive learning and aversive prediction errors
    Delgado, Mauricio R.
    Li, Jian
    Schiller, Daniela
    Phelps, Elizabeth A.
    [J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2008, 363 (1511) : 3787 - 3800