Potassium trimethylsilanolate mediated hydrolysis of nitriles to primary amides

被引：35

作者：

Merchant, KJ ^{[1
]}

机构：

[1] Merck Sharp & Dohme Res Labs, Neurosci Res Ctr, Dept Med Chem, Harlow CM20 2QR, Essex, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 19期

关键词：

hydrolysis; nitriles; amides; silicon and compounds;

D O I：

10.1016/S0040-4039(00)00482-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of nitriles with potassium trimethylsilanolate under mild anhydrous conditions readily yields the corresponding primary amides after a simple aqueous workup. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3747 / 3749

页数：3

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