T Cell Dynamics and the Response to HAART in a Cohort of HIV-1-Infected Elite Suppressors

被引：45

作者：

Sedaghat, Ahmad R. ^{[1
]}

Rastegar, Darius A. ^{[1
]}

O'Connell, Karen A. ^{[1
]}

Dinoso, Jason B. ^{[1
]}

Wilke, Claus O. ^{[2
,3
]}

Blankson, Joel N. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[2] Univ Texas Austin, Inst Cell & Mol Biol, Austin, TX 78712 USA

[3] Univ Texas Austin, Ctr Computat Biol & Bioinformat, Sect Integrat Biol, Austin, TX 78712 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2009年 / 49卷 / 11期

基金：

美国国家卫生研究院;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; VIRAL LOAD; HIV-1; INFECTION; ACTIVATION; DEPLETION; INDIVIDUALS; THERAPY; MODELS; COUNT; RNA;

D O I：

10.1086/648081

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Elite controllers or suppressors are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain undetectable viral loads. In this study, we show that most elite suppressors do not experience significant changes in T cell counts over a 10-year period. Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy ( HAART) led to a marked decrease in immune activation.

引用

页码：1763 / 1766

页数：4

共 15 条

[1] CD4+ T cell depletion in an untreated HIV type1-infected human leukocyte antigen-B*5801-positive patient with an undetectable viral load [J].

Andrade, Adriana ;

Bailey, Justin R. ;

Xu, Jie ;

Philp, Frances H. ;

Quinn, Thomas C. ;

Williams, Thomas M. ;

Ray, Stuart C. ;

Thomas, David L. ;

Blankson, Joel N. .

CLINICAL INFECTIOUS DISEASES, 2008, 46 (08) :E78-E82

[2] Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors [J].

Blankson, Joel N. ;

Bailey, Justin R. ;

Thayil, Seema ;

Yang, Hung-Chih ;

Lassen, Kara ;

Lai, Jun ;

Gandhi, Shiv K. ;

Siliciano, Janet D. ;

Williams, Thomas M. ;

Siliciano, Robert F. .

JOURNAL OF VIROLOGY, 2007, 81 (05) :2508-2518

[3] A comparison of viral loads between HIV-1-infected elite suppressors and individuals who receive suppressive highly active antiretroviral therapy [J].

Dinoso, Jason B. ;

Kim, Scott Y. ;

Siliciano, Robert F. ;

Blankson, Joel N. .

CLINICAL INFECTIOUS DISEASES, 2008, 47 (01) :102-104

[4] Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage [J].

Giorgi, JV ;

Hultin, LE ;

McKeating, JA ;

Johnson, TD ;

Owens, B ;

Jacobson, LP ;

Shih, R ;

Lewis, J ;

Wiley, DJ ;

Phair, JP ;

Wolinsky, SM ;

Detels, R .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (04) :859-870

[5] Declining CD4 T-cell counts in a person infected with nef-deleted HIV-1 [J].

Greenough, TC ;

Sullivan, JL ;

Desrosiers, RC .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (03) :236-237

[6] Simultaneous inference in general parametric models [J].

Hothorn, Torsten ;

Bretz, Frank ;

Westfall, Peter .

BIOMETRICAL JOURNAL, 2008, 50 (03) :346-363

[7] Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy [J].

Hunt, Peter W. ;

Brenchley, Jason ;

Sinclair, Elizabeth ;

McCune, Joseph M. ;

Roland, Michelle ;

Page-Shafer, Kimberly ;

Hsue, Priscilla ;

Emu, Brinda ;

Krone, Melissa ;

Lampiris, Harry ;

Douek, Daniel ;

Martin, Jeffrey N. ;

Deeks, Steven G. .

JOURNAL OF INFECTIOUS DISEASES, 2008, 197 (01) :126-133

[8] Spontaneous control of viral load and CD4 cell count progression among HIV-1 seroconverters [J].

Madec, Y ;

Boufassa, F ;

Porter, K ;

Meyer, L .

AIDS, 2005, 19 (17) :2001-2007

[9] FAILURE OF T-CELL HOMEOSTASIS PRECEDING AIDS IN HIV-1 INFECTION [J].

MARGOLICK, JB ;

MUNOZ, A ;

DONNENBERG, AD ;

PARK, LP ;

GALAI, N ;

GIORGI, JV ;

OGORMAN, MRG ;

FERBAS, J .

NATURE MEDICINE, 1995, 1 (07) :674-680

[10] QUANTITATION OF HIV-1 RNA IN PLASMA PREDICTS OUTCOME AFTER SEROCONVERSION [J].

MELLORS, JW ;

KINGSLEY, LA ;

RINALDO, CR ;

TODD, JA ;

HOO, BS ;

KOKKA, RP ;

GUPTA, P .

ANNALS OF INTERNAL MEDICINE, 1995, 122 (08) :573-579

← 1 2 →