Estramustine phosphate but not estramustine inhibits the interaction of microtubule associated protein 2 (MAP2) with actin filaments

被引：8

作者：

Pedrotti, B ^{[1
]}

Islam, K ^{[1
]}

机构：

[1] LEPETIT RES CTR,I-21040 GERENZANO,VA,ITALY

来源：

FEBS LETTERS | 1997年 / 403卷 / 02期

关键词：

microtubule-associated protein; high-molecular weight MAP; cytoskeleton; microfilament;

D O I：

10.1016/S0014-5793(96)01524-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of estramustine and estramustine phosphate (EP) on the interaction of microtubule associated protein 2 (MAP2) with actin has been examined, We show that (a) neither estramustine nor EP influences actin polymerisation (b) EP, but not estramustine, reduces the amount of MAP?. which cosediments with F-actin in a dose-dependent manner and (c) EP decreases the MAP2-induced crosslinking of F-actin into gelled networks. The data suggest, that unlike estramustine, EP interacts with MAP2 and modifies its interaction not only with microtubules but also with actin filaments. (C) 1997 Federation of European Biochemical Societies.

引用

页码：123 / 126

页数：4

共 21 条

[1] STOICHIOMETRY OF ESTRAMUSTINE PHOSPHATE BINDING TO MAP2 MEASURED BY THE DISASSEMBLY OF CHICK BRAIN MAP2 - TUBULIN MICROTUBULES [J].