Thermal behavior of water in micro-particles based on alginate gel

被引:21
作者
Bellich, Barbara [1 ]
Borgogna, Massimiliano [1 ]
Carnio, Damiano [1 ]
Cesaro, Attilio [1 ]
机构
[1] Univ Trieste, Dept Life Sci, Lab Phys & Macromol Chem, Trieste, Italy
关键词
Alginate gel beads; DSC; Gel dehydration; Water freezing and melting; Frozen and un-frozen water; Trehalose; HYDROPHILIC POLYMERS; DELIVERY; PROTEIN; TREHALOSE; CELLULOSE; RELEASE; FILMS; MICROENCAPSULATION; SURVIVAL; CALCIUM;
D O I
10.1007/s10973-009-0392-x
中图分类号
O414.1 [热力学];
学科分类号
070201 [理论物理];
摘要
Alginate has been established as a very versatile material in the preparation of hydrogel capsules for trapping therapeutic biomolecules and cells. The physico-chemical properties, the mechanism and the processing of gel formation are now well established. In the frame of a project aiming at the exploitation of encapsulation of therapeutic proteins in alginate gel particles, the procedure of preparation, characterization, gel-drying and re-hydrating has been explored for the shelf-life of the encapsulated biomolecules. Here, the results of a calorimetric study on the freezing and dehydration process of alginate micro-capsules is presented. The work aims at the description of water state(s) and its removal under "controlled conditions" in the presence of bioprotectant sugars.
引用
收藏
页码:871 / 878
页数:8
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