Notch signaling in lymphocyte development

被引：21

作者：

Guidos, CJ ^{[1
]}

机构：

[1] Hosp Sick Children, Res Inst, Program Dev Biol, Toronto, ON M5G 1X8, Canada

来源：

SEMINARS IN IMMUNOLOGY | 2002年 / 14卷 / 06期

关键词：

lineage commitment; lymphoid progenitors; Notch signaling;

D O I：

10.1016/S104453230200074X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokine and antigen receptor signals play well-characterized roles in promoting the survival and maturation of T and B lymphocyte progenitors through sequential developmental stages. Emerging studies suggest equally important roles for more ancient signaling pathways that evolved prior to the adaptive immune system in jawed vertebrates. In particular, there are at least two essential functions for the highly conserved Notch signaling pathway in lymphocyte development. First, Notch signals are essential for the development of T cell progenitors in the thymus and intestinal epithelium. Second, Notch signals are required to suppress B cell development in the thymus. This review will focus on focus on recent advances in our understanding of how Notch signaling regulates this developmental switch, as well as how Notch might regulate subsequent survival and cell fate decisions in developing T cells.

引用

页码：395 / 404

页数：10

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