Protection against polyoma virus-induced tumors is perforin-independent

被引：8

作者：

Byers, Anthony M. ^{[1
]}

Hadley, Annette ^{[1
]}

Lukacher, Aron E. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Pathol, Atlanta, GA 30322 USA

来源：

VIROLOGY | 2007年 / 358卷 / 02期

关键词：

polyoma virus; CD8 T cell; perforin; Fas; TNF; tumor; pathogenesis;

D O I：

10.1016/j.virol.2006.08.044

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

CD8 T cells are necessary for controlling tumors induced by mouse polyoma virus (PyV), but the effector mechanism(s) responsible have not been determined. We examined the PyV tumorigenicity in C57BL/6 mice mutated in Fas or carrying targeted disruptions in the perforin gene or in both TNF receptor type I and type II genes. Surprisingly, none of these mice developed tumors. Perforin/Fas double-deficient radiation bone marrow chimeric mice were also resistant to PyV-induced tumors. Anti-PyV CD8 T cells in perforin-deficient mice were found not to differ from wild type mice with respect to phenotype, capacity to produce cytokines or maintenance of memory T cells, indicating that perform does not modulate the PyV-specific CD8 T cell response. In addition, virus was cleared and persisted to similar extents in wild type and perforin-deficient mice. In summary, perforin/granzyme exocytosis is not an essential effector pathway for protection against PyV infection or tumorigenesis. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：485 / 492

页数：8

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