CRF ligands via Suzuki and Negishi couplings of 3-pyridyl boronic acids or halides with 2-benzyloxy-4-chloro-3-nitropyridine

被引:6
作者
Arvanitis, AG [1 ]
Arnold, CR
Fitzgerald, LW
Frietze, WE
Olson, RE
Gilligan, PJ
Robertson, DW
机构
[1] Bristol Myers Squibb Co, Discovery Chem Wilmington, Expt Stn, Wilmington, DE 19880 USA
[2] Bristol Myers Squibb Co, CNS Dis Res, Expt Stn, Wilmington, DE 19880 USA
关键词
D O I
10.1016/S0960-894X(02)00835-1
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A series of imidazo[4,5-b]pyridines with a 7-(3-pyridyl) substituent is described as high affinity CRF receptor ligands. Individual analogues were synthesized from key intermediates obtained via palladium-catalyzed coupling of 3-pyridyl zinc or boronic acid organometallic intermediates with 2-benzyloxy-4-chloro-3-nitropyridine 12. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:289 / 291
页数:3
相关论文
共 6 条
  • [1] ARVANTIS AG, 2002, BIOORG MED CHEM LETT, V12
  • [2] FUNCTIONALIZATION OF 2-METHOXY-6-METHYLPYRIDINE
    GRAY, MA
    KONOPSKI, L
    LANGLOIS, Y
    [J]. SYNTHETIC COMMUNICATIONS, 1994, 24 (10) : 1367 - 1379
  • [3] PYRIDINYLZINC HALIDES BY OXIDATIVE ADDITION OF ACTIVE ZINC WITH HALOPYRIDINES
    SAKAMOTO, T
    KONDO, Y
    MURATA, N
    YAMANAKA, H
    [J]. TETRAHEDRON LETTERS, 1992, 33 (37) : 5373 - 5374
  • [4] SAKAMOTO T, 1993, TETRAHEDRON, V49, P7913
  • [5] SU DB, 1991, TETRAHEDRON LETT, V32, P7689
  • [6] WILDE RG, 2000, 219 NAT M AM CHEM SO