Estrogen receptors and insulin-like growth factor-I receptors mediate estrogen-dependent synaptic plasticity

被引：51

作者：

Cardona-Gómez, GP ^{[1
]}

Trejo, JL ^{[1
]}

Fernandez, AM ^{[1
]}

Garcia-Segura, LM ^{[1
]}

机构：

[1] CSIC, Inst Cajal, E-28002 Madrid, Spain

来源：

NEUROREPORT | 2000年 / 11卷 / 08期

关键词：

estradiol; estrogen receptors; insulin-like growth factor-I; synapses; synaptic plasticity;

D O I：

10.1097/00001756-200006050-00027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies have shown that estradiol induces a transient disconnection of axe-somatic inhibitory synapses in the hypothalamic arcuate nucleus of adult ovariectomized rats. The synaptic disconnection is accompanied by an increase in the levels of insulin-like growth factor-I (IGF-I) in the arcuate nucleus, suggesting that IGF-I signaling may be involved in the estrogen-induced synaptic plasticity. The role of estrogen receptors and IGF-I receptors in the synaptic changes has been studied by assessing the number of axe-somatic synapses in ovariectomized rats treated with intracerebroventricular administration of the estrogen receptor antagonist ICI 182,780 and the IGF-I receptor antagonist JBI to ovariectomized rats. Estradiol administration resulted in a significant decrease in the number of axe-somatic synapses on arcuate neurons in control ovariectomized rats. Both the estrogen receptor antagonist and the IGF-I receptor antagonist blocked the estrogen-induced synaptic decrease. This finding suggest that estrogen-induced synaptic plasticity in the arcuate nucleus is dependent on the activation of both estrogen receptors and IGF-I receptors. NeuroReport 11:1735-1738 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：1735 / 1738

页数：4

共 22 条

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