Electrospun PLLA/MWNTs/HA hybrid nanofiber scaffolds and their potential in dental tissue engineering

被引：14

作者：

Deng, X. L. ^{[1
]}

Xu, M. M. ^{[1
]}

Li, D. ^{[2
]}

Sui, G. ^{[3
]}

Hu, X. Y. ^{[1
]}

Yang, X. P. ^{[3
]}

机构：

[1] Peking Univ, Sch Stomatol, Beijing 100081, Peoples R China

[2] Jiamusi Univ, Sch Stomatol, Heilongjiang 154002, Peoples R China

[3] Beijing Univ Chem & Technol, Key Lab Beijing City Preparat & Processing Novel, Beijing 100029, Peoples R China

来源：

BIOCERAMICS, VOL 19, PTS 1 AND 2 | 2007年 / 330-332卷

关键词：

electrospinning; poly(L-lactic acid); multi-walled carbon nanotubes; nanofiber; dental pulp stem cell; dental tissue engineering;

D O I：

10.4028/www.scientific.net/KEM.330-332.393

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Novel Poly(I-lactic acid) (PLLA)/ Multi-walled carbon nanotubes (MWNTs)/hydroxyapatite (HA) nanofibrous scaffolds with high porosity and well-controlled pore architectures were prepared via electrospinning techniques. The structure, morphology, molecular weight change of the scaffolds were investigated using scanning electron microscopy (SEM). The results noticed that the average diameter of hybrid nanofiber was similar to that of PLLA/HA fiber, but the surface of hybrid fibers was much coarser because of the introduction of MWNTs nano-particles. The biocompatibility of the scaffold has been investigated by human Dental Pulp Stem Cells (DPSCs) cell Culture on the scaffold. The preliminary results showed that cells were well adhered and proliferated on the hybrid scaffolds as well as PLLA/HA fibers. Based on the experimental observations, the aligned nanofibrous PLLA/MWNTs/HA scaffold could be used as a potential candidate scaffold in dental tissue engineering.

引用

页码：393 / +

页数：2

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