Genetics and osteoporosis

被引：39

作者：

Albagha, Omar M. E. ^{[1
]}

Ralston, Stuart H. ^{[1
]}

机构：

[1] Univ Edinburgh, Western Gen Hosp, Rheumatol Sect, Mol Med Ctr,Sch Mol & Clin Med, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2006年 / 32卷 / 04期

关键词：

D O I：

10.1016/j.rdc.2006.08.001

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Osteoporosis is a common disease characterized by reduced bone mass and increased risk for fracture. Genetic factors play an important role in regulating bone mass, bone turnover, and bone geometry and also contribute to the pathogenesis of fracture by mechanisms independent of effects on bone density. In this article, the authors review the techniques that have been used to identify genes that regulate susceptibility to osteoporosis and discuss the major candidate genes that have been implicated in the regulation of bone mass and susceptibility to osteoporotic fracture.

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页码：659 / +

页数：23

相关论文

共 124 条

[1]

Abu-Amer Y, 2000, J BIOL CHEM, V275, P27307

[2]

Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling [J].

Ai, M ;

Holmen, SL ;

Van Hul, W ;

Williams, BO ;

Warman, ML .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (12) :4946-4955

[3]

Bone biomechanical properties in LRP5 mutant mice [J].

Akhter, MP ;

Wells, DJ ;

Short, SJ ;

Cullen, DM ;

Johnson, ML ;

Haynatzki, GR ;

Babij, P ;

Allen, KM ;

Yaworsky, PJ ;

Bex, F ;

Recker, RR .

BONE, 2004, 35 (01) :162-169

[4]

Association of oestrogen receptor α gene polymorphisms with postmenopausal bone loss, bone mass, and quantitative ultrasound properties of bone [J].

Albagha, OME ;

Pettersson, U ;

Stewart, A ;

McGuigan, FEA ;

MacDonald, HM ;

Reid, DM ;

Ralston, SH .

JOURNAL OF MEDICAL GENETICS, 2005, 42 (03) :240-246

[5]

Linkage disequilibrium between polymorphisms in the human TNFRSF1B gene and their association with bone mass in perimenopausal women [J].

Albagha, OME ;

Tasker, PN ;

McGuigan, FEA ;

Reid, DM ;

Ralston, SH .

HUMAN MOLECULAR GENETICS, 2002, 11 (19) :2289-2295

[6]

Estrogen receptor α gene polymorphisms and bone mineral density:: Haplotype analysis in women from the United Kingdom [J].

Albagha, OME ;

McGuigan, FEA ;

Reid, DM ;

Ralston, SH .

JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (01) :128-134

[7]

Multipoint quantitative-trait linkage analysis in general pedigrees [J].

Almasy, L ;

Blangero, J .

AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (05) :1198-1211

[8]

Andrew T, 2005, J BONE MINER RES, V20, P67, DOI [10.1359/jbmr.2005.20.1.67, 10.1359/JBMR.041015]

[9]

A vitamin D receptor gene polymorphism in the translation initiation codon: Effect on protein activity and relation to bone mineral density in Japanese women [J].

Arai, H ;

Miyamoto, KI ;

Taketani, Y ;

Yamamoto, H ;

Iemori, Y ;

Morita, K ;

Tonai, T ;

Nishisho, T ;

Mori, S ;

Takeda, E .

JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 (06) :915-921

[10]

The polymorphism in the caudal-related homeodomain protein Cdx-2 binding element in the human vitamin D receptor gene [J].

Arai, H ;

Miyamoto, KI ;

Yoshida, M ;

Yamamoto, H ;

Taketani, Y ;

Morita, K ;

Kubota, M ;

Yoshida, S ;

Ikeda, M ;

Watabe, F ;

Kanemasa, Y ;

Takeda, E .

JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (07) :1256-1264

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