Translocation (8;12;21)(q22.1;q24.1;q22.1): A new masked type of t(8;21)(q22;q22) in a patient with acute myeloid leukemia

被引：15

作者：

Saitoh, K

Miura, I

Ohshima, A

Takahashi, N

Kume, M

Utsumi, S

Kobayashi, Y

Hashimoto, K

Hatano, Y

Nimura, T

Saito, M

Enomoto, K

Ohhira, M

Shimizu, K

Ohki, M

Miura, AB

机构：

[1] AKITA UNIV, SCH MED, DEPT INTERNAL MED 3, AKITA 010, JAPAN

[2] AKITA UNIV, SCH MED, DEPT PATHOL 1, AKITA 010, JAPAN

[3] NATL CANC CTR, RES INST, DIV RADIOBIOL, TOKYO 104, JAPAN

来源：

CANCER GENETICS AND CYTOGENETICS | 1997年 / 96卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(96)00320-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The translocation t(8; 21)(q22; q22) is found in 40% of cases of acute myeloid leukemia (AML) designated as the subtype M2 in the French-American-British (FAB) classification. The 8; 21 translocation is clinically of interest because patients with this subtype have a good prognosis. We describe a masked type of the translocation, t(8; 12; 21)(q22.1; q24.1; q22.1). The translocation was first interpreted as t(8; 12)(q22; q24) based on cytogenetics, but was reevaluated as a result of Southern blot and fluorescence in situ hybridization (FISH) analyses. (C) Elsevier Science Inc., 1997.

引用

页码：111 / 114

页数：4

共 16 条

[1]

[Anonymous], CHROMOSOMES HUMAN CA

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