The relationship between the roles of BRCA genes in DNA repair and cancer predisposition

被引：269

作者：

Tutt, A ^{[1
]}

Ashworth, A ^{[1
]}

机构：

[1] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

来源：

TRENDS IN MOLECULAR MEDICINE | 2002年 / 8卷 / 12期

关键词：

D O I：

10.1016/S1471-4914(02)02434-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The proteins encoded by the breast-cancer-susceptibility genes, BRCA1 and BRCA2 have recently been implicated in DNA-repair processes, thereby improving our understanding of how the loss of these genes contributes to cancer initiation and progression. It appears that the role of BRCA1 in DNA repair, which could involve the integration of several pathways, is broader than that of BRCA2. BRCA1 functions in the signalling of DNA damage and its repair by homologous recombination, nucleotide-excision repair and possibly non-homologous end-joining. BRCA2 has a more specific role in DNA repair, regulating the activity of RAD51, which is required for homologous recombination. An improved understanding of the interactions of BRCA1 and BRCA2 with other proteins in large macromolecular complexes is helping to reveal their exact role in DNA repair.

引用

页码：571 / 576

页数：6

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