Release of vasoactive cytokines by antibody-enhanced dengue virus infection of a human mast cell/basophil line

被引：110

作者：

King, CA

Marshall, JS

Alshurafa, H

Anderson, R ^{[1
]}

机构：

[1] Dalhousie Univ, Dept Microbiol & Immunol, Halifax, NS B3H 4H7, Canada

[2] Dalhousie Univ, Dept Pathol, Halifax, NS B3H 4H7, Canada

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 15期

关键词：

D O I：

10.1128/JVI.74.15.7146-7150.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report here the first demonstration of dengue virus infection and vasoactive cytokine response of a cell of the mast cell/basophil lineage. Infection of KU812 cells was dependent on dengue-specific antibody and gave rise to infectious virions. This antibody-enhanced dengue virus infection triggered a four- to fivefold increase in the release of interleukin-1 beta (IL-1 beta) and a modest increase for IL-6 but not for an alternate cytokine, granulocyte-macrophage colony-stimulating factor. The results suggest a potential role for mast cells/basophils in the pathogenesis of dengue virus-induced disease.

引用

页码：7146 / 7150

页数：5

共 62 条

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