Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not In primary tumours

被引：51

作者：

Özdag, H

Batley, SJ

Försti, A

Iyer, NG

Daigo, Y

Boutell, J

Arends, MJ

Ponder, BAJ

Kouzarides, T

Caldas, C ^{[1
]}

机构：

[1] Univ Cambridge, Dept Oncol, Canc Genom Program, Hutchison MRC Res Ctr, Cambridge CB2 2XZ, England

[2] Univ Cambridge, Dept Pathol, Cambridge CB2 1QR, England

[3] Univ Cambridge, Wellcome CRC Inst, Cambridge CB2 1QR, England

[4] Univ Cambridge, Addenbrookes Hosp, Dept Pathol, Cambridge CB2 2QQ, England

来源：

BRITISH JOURNAL OF CANCER | 2002年 / 87卷 / 10期

关键词：

P300; CBP; PCAF; mutations; epithelial cancers;

D O I：

10.1038/sj.bjc.6600554

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study we screened the histone acetyltransferases CBP and PCAF for mutations in human epithelial cancer cell lines and primary tumours. We identified two CBP truncations (both in cell lines), seven PCAF missense variants and four CBP intronic microdeletions. These data suggest that neither gene is commonly inactivated in human epithelial cancers. (C) 2002 Cancer Research UK.

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收藏

页码：1162 / 1165

页数：4

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