Plasticity in fast synaptic inhibition of adult oxytocin neurons caused by switch in GABA(A) receptor subunit expression

被引：187

作者：

Brussaard, AB

Kits, KS

Baker, RE

Willems, WPA

LeytingVermeulen, JW

Voorn, P

Smit, AB

Bicknell, RJ

Herbison, AE

机构：

[1] VRIJE UNIV AMSTERDAM,NEUROSCI RES INST,MOL NEUROBIOL SECT,NL-1081 HV AMSTERDAM,NETHERLANDS

[2] VRIJE UNIV AMSTERDAM,NEUROSCI RES INST,DEPT ANAT,NL-1081 HV AMSTERDAM,NETHERLANDS

[3] BABRAHAM INST,NEUROENDOCRINOL LAB,CAMBRIDGE CB2 4AT,ENGLAND

来源：

NEURON | 1997年 / 19卷 / 05期

关键词：

D O I：

10.1016/S0896-6273(00)80401-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We found that magnocellular oxytocin neurons in adult female rats exhibit an endogenous GABA(A) receptor subunit switch around parturition: a decrease in alpha 1:alpha 2 subunit mRNA ratio correlated with a decrease in allopregnanolone potentiation and increase in decay time constant of the GABA(A) receptor-mediated IPSCs in these cells. The causal relationship between changes in alpha 1:alpha 2 mRNA ratio and the ion channel kinetics was confirmed using in vitro antisense deletion. Further, GABA(A) receptors exhibited a tonic inhibitory influence upon oxytocin release in vivo, and allopregnanolone helped to restrain oxytocin neuron in vitro firing only before parturition, when the alpha 1:alpha 2 subunit mRNA ratio was still high. Such observations provide evidence for the physiological significance of GABA(A) receptor subunit heterogeneity and plasticity in the adult brain.

引用

页码：1103 / 1114

页数：12

共 68 条

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