Anti-alpha 4 integrin antibody induces apoptosis in murine thymocytes and staphylococcal enterotoxin B-activated lymph node T cells

被引：31

作者：

Tchilian, EZ ^{[1
]}

Owen, JJT ^{[1
]}

Jenkinson, EJ ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,SCH MED,DEPT ANAT,CTR CLIN RES IMMUNOL & SIGNALLING,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

来源：

IMMUNOLOGY | 1997年 / 92卷 / 03期

关键词：

D O I：

10.1046/j.1365-2567.1997.00351.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have shown that an antibody (9C10) to the alpha 4 integrin induces apoptosis in murine immature CD4(+) CD8(+) thymocytes and in activated (but not resting) mature lymph node T cells. In both cases, apoptosis is blocked by the highly selective protein kinase C (PKC) inhibitor Ro31.8425, suggesting that 9C10 induces signalling through the alpha 4 integrin resulting in PKC activation leading to apoptosis. Overall, our results indicate the potential role of the alpha 4 integrin-mediated interactions in apoptosis induction during T-cell development and following mature T-cell activation.

引用

页码：321 / 327

页数：7

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