Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice

被引:1125
作者
Hautamaki, RD
Kobayashi, DK
Senior, RM
Shapiro, SD
机构
[1] WASHINGTON UNIV, SCH MED, BAMES JEWISH HOSP, DEPT INTERNAL MED, ST LOUIS, MO 63110 USA
[2] WASHINGTON UNIV, SCH MED, BAMES JEWISH HOSP, DEPT CELL BIOL & PHYSIOL, ST LOUIS, MO 63110 USA
关键词
D O I
10.1126/science.277.5334.2002
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
To determine which proteinases are responsible for the lung destruction characteristic of pulmonary emphysema, macrophage elastase-deficient (MME-/-) mice were subjected to cigarette smoke. In contrast to wild-type mice, MME-/- mice did not have increased numbers of macrophages in their lungs and did not develop emphysema in response to long-term exposure to cigarette smoke. Smoke-exposed MME-/- mice that received monthly intratracheal instillations of monocyte chemoattractant protein-1 showed accumulation of alveolar macrophages but did not develop air space enlargement. Thus, macrophage elastase is probably sufficient for the development of emphysema that results from chronic inhalation of cigarette smoke.
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页码:2002 / 2004
页数:3
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