The role of angiogenesis in the pathogenesis of psoriasis

被引：60

作者：

Chua, Ramon Alvin ^{[1
]}

Arbiser, Jack L. ^{[1
]}

机构：

[1] Emory Univ, Dept Dermatol, Sch Med, Atlanta Vet Adm Hosp, Atlanta, GA 30322 USA

来源：

AUTOIMMUNITY | 2009年 / 42卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Angiogenesis; pathogenesis; psoriasis; autoimmune; skin; ENDOTHELIAL GROWTH-FACTOR; NF-KAPPA-B; SINGLE-NUCLEOTIDE POLYMORPHISMS; TNF-ALPHA; ATOPIC-DERMATITIS; ANTIMICROBIAL PEPTIDES; KERATINOCYTE-RESPONSE; CELL PROLIFERATION; ALTERED EXPRESSION; INSULIN-RESISTANCE;

D O I：

10.1080/08916930903002461

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Psoriasis is a multifactorial skin disorder with known systemic consequences. While most recent studies point to a predominantly Th17-driven process, psoriasis also lies at the crossroads linking the pathways of angiogenesis and inflammation. Mediators such as VEGF and angiopoietin-2 play significant roles in the pathophysiology and may even account for the maintenance of the chronic inflammatory state. Targets in this shared pathway may offer alternative avenues for therapy.

引用

页码：574 / 579

页数：6

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