Inhibition of tyrosine kinases by sunitinib associated with focal segmental glomerulosclerosis lesion in addition to thrombotic microangiopathy

被引：43

作者：

Costero, Olga ^{[1
]}

Luz Picazo, Mari ^{[2
]}

Zamora, Pilar ^{[3
]}

Romero, Sara ^{[1
]}

Martinez-Ara, Jorge ^{[1
]}

Selgas, Rafael ^{[1
]}

机构：

[1] La Paz Univ Hosp, Dept Nephrol, Madrid, Spain

[2] La Paz Univ Hosp, Dept Histopathol, Madrid, Spain

[3] La Paz Univ Hosp, Dept Med Oncol, Madrid, Spain

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2010年 / 25卷 / 03期

关键词：

focal segmental glomerulosclerosis; renal cell carcinoma; sunitinib; thrombotic microangiopathy; tyrosine kinase inhibitors; NEPHROTIC SYNDROME; HYPERTENSION; PROTEINURIA; THERAPY; CANCER; TRIAL;

D O I：

10.1093/ndt/gfp666

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Sunitinib is an orally administered inhibitor of tyrosine kinases and has become the standard of care for many patients with metastatic renal cell carcinoma. Its use has been associated with renal toxicity in some patients. We report a patient with a metastatic clear-cell renal carcinoma who showed arterial hypertension, nephrotic syndrome and azotaemia 10 months after treatment with sunitinib. The renal biopsy revealed focal segmental glomerulosclerosis (FSGS) in addition to thrombotic microangiopathy (TMA), and the complete syndrome disappeared 6 months after sunitinib withdrawal. To our knowledge, this is the first case of FSGS associated to TMA secondary to sunitinib treatment. We discuss the possible glomerular pathomechanism.

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收藏

页码：1001 / 1003

页数：3

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