A web of circadian pacemakers

被引：602

作者：

Schibler, U

Sassone-Corsi, P

机构：

[1] Univ Geneva, NCCR Frontiers Genet Sci 2, Dept Mol Biol, CH-1211 Geneva 4, Switzerland

[2] Inst Genet & Biol Mol & Cellulaire, F-67404 Strasbourg, France

来源：

CELL | 2002年 / 111卷 / 07期

关键词：

D O I：

10.1016/S0092-8674(02)01225-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian circadian timing system is composed of almost as many individual clocks as there are cells. These countless oscillators have to be synchronized by a central pacemaker to coordinate temporal physiology and behavior. Recently, there has been some progress in understanding the relationship and communication, mechanisms between central and peripheral clocks.

引用

页码：919 / 922

页数：4

共 20 条

[1] Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts
Balsalobre, A
Marcacci, L
Schibler, U
[J]. CURRENT BIOLOGY, 2000, 10 (20) : 1291 - 1294
[2] Rhythms of mammalian body temperature can sustain peripheral circadian clocks
Brown, SA
Zumbrunn, G
Fleury-Olela, F
Preitner, N
Schibler, U
[J]. CURRENT BIOLOGY, 2002, 12 (18) : 1574 - 1583
[3] Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus
Cheng, MY
Bullock, CM
Li, CY
Lee, AG
Bermak, JC
Belluzzi, J
Weaver, DR
Leslie, FM
Zhou, QY
[J]. NATURE, 2002, 417 (6887) : 405 - 410
[4] Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
Damiola, F
Le Minh, N
Preitner, N
Kornmann, B
Fleury-Olela, F
Schibler, U
[J]. GENES & DEVELOPMENT, 2000, 14 (23) : 2950 - 2961
[5] The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo
Fu, LN
Pelicano, H
Liu, JS
Huang, P
Lee, CC
[J]. CELL, 2002, 111 (01) : 41 - 50
[6] Peripheral clocks and their role in circadian timing: insights from insects
Giebultowicz, JM
[J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2001, 356 (1415) : 1791 - 1799
[7] Time for plants. Progress in plant chronobiology
Golden, SS
Strayer, C
[J]. PLANT PHYSIOLOGY, 2001, 125 (01) : 98 - 101
[8] Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop
Hirata, H
Yoshiura, S
Ohtsuka, T
Bessho, Y
Harada, T
Yoshikawa, K
Kageyama, R
[J]. SCIENCE, 2002, 298 (5594) : 840 - 843
[9] Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured rat-1 fibroblasts
Hirota, T
Okano, T
Kokame, K
Shirotani-Ikejima, H
Miyata, T
Fukada, Y
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (46) : 44244 - 44251
[10] Kondo T, 2000, BIOESSAYS, V22, P10, DOI 10.1002/(SICI)1521-1878(200001)22:1<10::AID-BIES4>3.0.CO

← 1 2 →