Synthesis of glycosylated polyethylenimine with reduced toxicity and high transfecting efficiency

被引：23

作者：

Leclercq, F

Dubertret, C

Pitard, B

Scherman, D

Herscovici, J

机构：

[1] ENSCP, AVENTIS UMR 7001, CNRS,Unite Mixte, Lab Chim Bioorgan & Biotechnol Mol & Cellulaire, F-75231 Paris, France

[2] CRVA, AVENTIS, F-94403 Vitry, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(00)00195-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A safe and efficient synthesis of glycosylated polyethylenimine using titanium (IV) isopropoxide and sodium borohydride has been carried out as a substitute for the highly toxic sodium cyanoborohydride method currently used. Polyplexes formed between DNA and the various glycosylated polyethylenimines appeared to be much less cytotoxic than polyethylenimine (PEI)/DNA polyplexes. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1233 / 1235

页数：3

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