Dysidotronic acid, a new and selective human phospholipase A2 inhibitor from the sponge Dysidea sp.

被引：23

作者：

Giannini, C

Debitus, C

Posadas, I

Payá, M

D'Auria, MV

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] IRD, ORSTOM, Ctr Noumea, Noumea 98848, New Caledonia

[3] Univ Valencia, Dept Farmacol, E-46100 Valencia, Spain

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(00)00362-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new bioactive sesquiterpenoid, named dysidotronic acid 1, with a rearranged drimane skeleton has been isolated from the sponge Dysidea sp. from Vanuatu islands, along with bolinaquinone 2. The chemical structure of 1 was determined on the basis of spectroscopic data. Dysidotronic acid significantly inhibited human synovial phospholipase A(2) (PLA(2)) at 10 mu M, with an IC50 value of 2.6 mu M and a higher selectivity and potency towards this enzyme than the reference inhibitor manoalide. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3257 / 3260

页数：4

共 17 条

[1] EVALUATION OF NEW SESQUITERPENE QUINONES FROM 2 DYSIDEA SPONGE SPECIES AS INHIBITORS OF PROTEIN TYROSINE KINASE [J].