Functionality of unspliced XBP1 is required to explain evolution of overlapping reading frames

被引：31

作者：

Nekrutenko, Anton ^{[1
]}

He, Jianbin ^{[1
]}

机构：

[1] Penn State Univ, Huck Inst Life Sci, Ctr Comparat Genom & Bioinformat, Dept Biochem & Mol Biol, University Pk, PA 16802 USA

来源：

TRENDS IN GENETICS | 2006年 / 22卷 / 12期

关键词：

D O I：

10.1016/j.tig.2006.09.012

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Eukaryotic genes with overlapping reading frames exemplify some of the most striking biological phenomena. Transcript of one such gene, the gene encoding X-box protein (XBP1), has evolved a mechanism for 'on-demand' switching of translation between two overlapping reading frames. Despite the existence of this elaborate system, only one reading frame was believed to be functional. Here, we show that XBP1 evolves in a fashion that is only consistent with functionality of both reading frames. Our study provides a novel evolutionary framework for the analysis of loci with overlapping reading frames, which can be used for identification and analyses of novel dual-coding genes.

引用

页码：645 / 648

页数：4

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