Endoplasmic reticulum stress and apoptosis

被引：154

作者：

Faitova, Jitka ^{[1
]}

Krekac, Daniel ^{[1
]}

Hrstka, Roman ^{[1
]}

Vojtesek, Borivoj ^{[1
]}

机构：

[1] Masaryk Mem Canc Inst, Dept Pathol & Expt Oncol, Brno 65653, Czech Republic

来源：

CELLULAR & MOLECULAR BIOLOGY LETTERS | 2006年 / 11卷 / 04期

关键词：

endoplasmic reticulum; apoptosis; p53; scotin;

D O I：

10.2478/s11658-006-0040-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell death is an essential event in normal life and development, as well as in the pathophysiological processes that lead to disease. It has become clear that each of the main cellular organelles can participate in cell death signalling pathways, and recent advances have highlighted the importance of the endoplasmic reticulum (ER) in cell death processes. In cells, the ER functions as the organelle where proteins mature, and as such, is very responsive to extracellular-intracellular changes of environment. This short overview focuses on the known pathways of programmed cell death triggering from or involving the ER.

引用

页码：488 / 505

页数：18

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