Mechanistic and kinetic considerations of protein splicing

被引：53

作者：

Evans, TC ^{[1
]}

Xu, MQ ^{[1
]}

机构：

[1] New England Biolabs Inc, Beverly, MA 01915 USA

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 12期

关键词：

D O I：

10.1021/cr9601369

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mechanistic... Much has been learned about inteins. Finding multiple inteins coupled with mutagenic studies highlighted conserved functionally important amino acid residues. The relevance of the splice junction amino acid residues became clear with the determination of the protein splicing mechanism. Crystal structures, kinetic studies, and the discovery of an inhibitor further added to the understanding of inteins and the splicing reaction.

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页码：4869 / 4883

页数：15

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