Oxytocin receptor polymorphisms and adult attachment style in patients with depression

被引：188

作者：

Costa, Barbara ^{[2
]}

Pini, Stefano ^{[1
]}

Gabelloni, Pamela ^{[1
]}

Abelli, Marianna ^{[1
]}

Lari, Lisa ^{[1
]}

Cardini, Alessandra ^{[1
]}

Muti, Matteo ^{[1
]}

Gesi, Camilla ^{[1
]}

Landi, Stefano ^{[3
]}

Galderisi, Silvana ^{[4
]}

Mucci, Armida ^{[4
]}

Lucacchini, Antonio ^{[1
]}

Cassano, Giovanni B. ^{[1
]}

Martini, Claudia ^{[1
]}

机构：

[1] Univ Pisa, Dept Psychiat Neurobiol Pharmacol & Biotechnol, I-56126 Pisa, Italy

[2] Univ Pisa, Dept Human Morphol & Appl Biol, I-56126 Pisa, Italy

[3] Univ Pisa, Dept Biol, I-56126 Pisa, Italy

[4] Univ Naples SUN, Dept Psychiat, Naples, Italy

来源：

PSYCHONEUROENDOCRINOLOGY | 2009年 / 34卷 / 10期

关键词：

Oxytocin; Oxytocin receptor; Single nucleotide polymorphisms; Haplotype; Adult attachment style; Unipolar depression; Bipolar depression; SEPARATION ANXIETY; SOCIAL ATTACHMENT; MAJOR DEPRESSION; WORKING MODELS; RATING-SCALE; VASOPRESSIN; POPULATION; QUESTIONNAIRE; HYPOTHALAMUS; ASSOCIATION;

D O I：

10.1016/j.psyneuen.2009.05.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Much evidence of an association between specific attachment styles and depression prompted us to investigate, in depressive disorders, the potential rote of polymorphisms within the gene encoding the receptor of the main neurohormone involved in attachment processes, oxytocin. For this purpose, two single nucleotide polymorphisms (SNPs), 6930G>A (rs53576) and 9073G>A (rs2254298), within the oxytocin receptor gene (OXTR), were studied in a cohort of 185 patients with major depression (50.3%) or bipolar I or 11 disorders (49.7%) and 192 matched healthy controls. A positive association between the GG genotype of OXTR SNPs (6930G>A or 9073G>A) and unipolar depression was demonstrated. In this group, GG individuals showed high scores on Attachment Style Questionnaire factors that have been previously associated with depression. Moreover, the GG genotype was also associated with high levels of adult separation anxiety. These findings support the involvement of the oxytocinergic system in the mechanisms that underlie depression and specific adult attachment styles. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1506 / 1514

页数：9

共 49 条

[11] Recurrent depression and the role of adult attachment: A prospective and a retrospective study [J].

Conradi, Henk Jan ;

de Jonge, Peter .

JOURNAL OF AFFECTIVE DISORDERS, 2009, 116 (1-2) :93-99

[12]

Cubells JF, 1997, AM J MED GENET, V74, P374, DOI 10.1002/(SICI)1096-8628(19970725)74:4<374::AID-AJMG7>3.0.CO

[13]

2-P

[14] Evidence of Dysregulated Peripheral Oxytocin Release Among Depressed Women [J].

Cyranowski, Jill M. ;

Hofkens, Tara L. ;

Frank, Ellen ;

Seltman, Howard ;

Cai, Hou-Ming ;

Amico, Janet A. .

PSYCHOSOMATIC MEDICINE, 2008, 70 (09) :967-975

[15] Oxytocin, Vasopressin, and the Neurogenetics of Sociality [J].

Donaldson, Zoe R. ;

Young, Larry J. .

SCIENCE, 2008, 322 (5903) :900-904

[16]

Donnellan MB, 2008, PERS SOC PSYCHOL B, V34, P3, DOI 10.1177/0146167207309199

[17]

Feeney J. A., 1994, ATTACHMENT ADULTS CL, P128, DOI DOI 10.1037/T29439-000

[18]

First M.B., 2002, STRUCTURED CLIN INTE

[19] On the dimensionality of the Attachment Style Questionnaire in Italian clinical and nonclinical participants [J].

Fossati, A ;

Feeney, JA ;

Donati, D ;

Donini, M ;

Novella, L ;

Bagnato, M ;

Acquarini, E ;

Maffei, C .

JOURNAL OF SOCIAL AND PERSONAL RELATIONSHIPS, 2003, 20 (01) :55-79

[20] Attachment and psychological adaptation in high exposure survivors of the September 11th attack on the World Trade Center [J].

Fraley, RC ;

Fazzari, DA ;

Bonanno, GA ;

Dekel, S .

PERSONALITY AND SOCIAL PSYCHOLOGY BULLETIN, 2006, 32 (04) :538-551

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