Perforin: more than just an effector molecule

被引：84

作者：

Stepp, SE

Mathew, PA

Bennett, M

de Saint Basile, G

Kumar, V

机构：

[1] Univ Texas, SW Med Ctr, Grad Program Immunol, Dallas, TX 75235 USA

[2] UNT Hlth Sci Ctr, Dept Mol Biol & Immunol, Ft Worth, TX 76107 USA

[3] Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX 75235 USA

[4] INSERM, Unite Rech Dev Normal & Pathol Syst Immunitaire, U429, Paris, France

[5] Univ Chicago, Sch Med, Dept Pathol, Chicago, IL 60637 USA

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 06期

关键词：

D O I：

10.1016/S0167-5699(00)01622-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Perforin mediates the destruction of virus-infected or transformed cells. However, the finding that perforin deficiency is the underlying cause of familial hemaphagocytic lymphohistiocytosis indicates that it also regulates the immune response.

引用

页码：254 / 256

页数：5

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