Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis

被引：427

作者：

Reznick, Richard M.

Zong, Haihong

Li, Ji

Morino, Katsutaro

Moore, Irene K.

Yu, Hannah J.

Liu, Zhen-Xiang

Dong, Jianying

Mustard, Kirsty J.

Hawley, Simon A.

Befroy, Douglas

Pypaert, Marc

Hardie, D. Grahame

Young, Lawrence H.

Shulman, Gerald I. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA

[2] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06510 USA

[3] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06510 USA

[4] Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USA

[5] Univ Dundee, Div Mol Physiol, Dundee DD1 4HN, Scotland

来源：

CELL METABOLISM | 2007年 / 5卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.cmet.2007.01.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies have demonstrated a strong relationship between aging-associated reductions in mitochondrial function, dysregulated intracellular lipid metabolism, and insulin resistance. Given the important role of the AMP-activated protein kinase (AMPK) in the regulation of fat oxidation and mitochondrial biogenesis, we examined AMPK activity in young and old rats and found that acute stimulation of AMPK-alpha 2 activity by 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) and exercise was blunted in skeletal muscle of old rats. Furthermore, mitochondrial biogenesis in response to chronic activation of AMPK with D-guanidinopropionic acid (beta-GPA) feeding was also diminished in old rats. These results suggest that aging-associated reductions in AMPK activity may be an important contributing factor in the reduced mitochondrial function and dysregulated intracellular lipid metabolism associated with aging.

引用

页码：151 / 156

页数：6

共 20 条

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