Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

被引：3595

作者：

Ivanov, Ivaylo I. ^{[2
,3
]}

Atarashi, Koji ^{[1
]}

Manel, Nicolas ^{[2
,3
]}

Brodie, Eoin L. ^{[5
]}

Shima, Tatsuichiro ^{[8
]}

Karaoz, Ulas ^{[5
]}

Wei, Dongguang ^{[6
]}

Goldfarb, Katherine C. ^{[5
]}

Santee, Clark A. ^{[5
]}

Lynch, Susan V. ^{[7
]}

Tanoue, Takeshi ^{[1
]}

Imaoka, Akemi ^{[8
]}

Itoh, Kikuji ^{[9
]}

Takeda, Kiyoshi ^{[1
]}

Umesaki, Yoshinori ^{[8
]}

Honda, Kenya ^{[1
,10
]}

Littman, Dan R. ^{[2
,3
,4
]}

机构：

[1] Osaka Univ, Lab Immune Regulat, Grad Sch Med, WPI Immunol Frontier Res Ctr, Osaka 5650871, Japan

[2] NYU, Sch Med, Mol Pathogenesis Program, Kimmel Ctr Biol, New York, NY 10016 USA

[3] NYU, Sch Med, Med Skirball Inst, New York, NY 10016 USA

[4] NYU, Sch Med, Howard Hughes Med Inst, New York, NY 10016 USA

[5] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Earth Sci, Ctr Environm Biotechnol, Berkeley, CA 94720 USA

[6] Carl Zeiss SMT Inc, Nanotechnol Syst Div, Peabody, MA 01960 USA

[7] Univ Calif San Francisco, Dept Med, Div Gastroenterol, San Francisco, CA 94143 USA

[8] Yakult Cent Inst Microbiol Res, Tokyo 1868650, Japan

[9] Univ Tokyo, Dept Vet Publ Hlth, Bunkyo Ku, Tokyo 1138657, Japan

[10] Japan Sci & Technol Agcy, Kawaguchi, Saitama 3320012, Japan

来源：

CELL | 2009年 / 139卷 / 03期

基金：

美国能源部; 美国国家卫生研究院;

关键词：

MURINE GASTROINTESTINAL-TRACT; MUCOSAL IMMUNE-SYSTEM; T-HELPER-CELLS; AUTOIMMUNE INFLAMMATION; HOST-DEFENSE; TGF-BETA; DIFFERENTIATION; INNATE; MICE; IL-23;

D O I：

10.1016/j.cell.2009.09.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gastrointestinal tract of mammals is inhabited by hundreds of distinct species of commensal microorganisms that exist in a mutualistic relationship with the host. How commensal microbiota influence the host immune system is poorly understood. We show here that colonization of the small intestine of mice with a single commensal microbe, segmented filamentous bacterium (SFB), is sufficient to induce the appearance of CD4(+) T helper cells that produce IL-17 and IL-22 (Th17 cells) in the lamina propria. SFB adhere tightly to the surface of epithelial cells in the terminal ileum of mice with Th17 cells but are absent from mice that have few Th17 cells. Colonization with SFB was correlated with increased expression of genes associated with inflammation and antimicrobial defenses and resulted in enhanced resistance to the intestinal pathogen Citrobacter rodentium. Thus, manipulation of this commensal-regulated pathway may provide new opportunities for enhancing mucosal immunity and treating autoimmune disease.

引用

页码：485 / 498

页数：14

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