Efficient synthesis of 4-ethoxycarbonyl pyrazolin-5-one derivatives

被引：10

作者：

Jung, JC

Watkins, EB

Avery, MA

机构：

[1] Univ Mississippi, Dept Med Chem, Sch Pharm, University, MS 38677 USA

[2] Univ Mississippi, Dept Chem, University, MS 38677 USA

[3] Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA

来源：

SYNTHETIC COMMUNICATIONS | 2002年 / 32卷 / 24期

关键词：

pyrazolin-5-ones; cyclocondensation; acyl diethylmalonates;

D O I：

10.1081/SCC-120015395

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Concise and efficient methods for the preparation of 3-substituted 4-ethoxycarbonylpyrazolin-5-ones are described. The synthetic strategies involve carbon-acylation in the presence of base, followed by ring cyclization With hydrazine or hydrazine monohydrochloride.

引用

页码：3767 / 3777

页数：11

共 20 条

[1] REACTIONS OF UNSATURATED TETRA-ESTERS AND TRI-ESTERS WITH HYDRAZINE HYDRATE AND SEMICARBAZIDE HYDROCHLORIDE [J].