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Tomographic molecular imaging and 3D quantification within adult mouse organs

被引：156
作者：
Alanentalo, Tomas
Asayesh, Amir
Morrison, Harris
Loren, Christina E.
Holmberg, Dan
Sharpe, James
Ahlgren, Ulf [1 ]
机构：
[1] Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
[2] Umea Univ, Ctr Mol Med, S-90187 Umea, Sweden
[3] Umea Univ, Dept Med & Clin Genet, S-90185 Umea, Sweden
来源：
NATURE METHODS | 2007年 / 4卷 / 01期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1038/NMETH985
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A convenient technology to quantify three-dimensional (3D) morphological features would have widespread applications in biomedical research. Based on combined improvements in sample preparation, tomographic imaging and computational processing, we present a procedure for high-resolution 3D quantification of structures within intact adult mouse organs. Using the nonobese diabetic (NOD) mouse model, we demonstrate a correlation between total islet beta-cell volume and the onset of type-1 diabetes.
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页码：31 / 33
页数：3
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