Radioprotection by short-term oxidative preconditioning: Role of manganese superoxide dismutase

被引：11

作者：

Belikova, Natalia A. ^{[2
,3
]}

Glumac, Ashley ^{[2
,3
]}

Rafikov, Ruslan ^{[2
,3
]}

Jiang, Jianfei ^{[2
,3
]}

Greenberger, Joel S. ^{[4
]}

Kagan, Valerian E. ^{[2
,3
]}

Bayir, Huelya ^{[1
,3
]}

机构：

[1] Univ Pittsburgh, Dept Crit Care Med, Pittsburgh, PA 15201 USA

[2] Univ Pittsburgh, Dept Environm & Occupat Hlth, Pittsburgh, PA 15219 USA

[3] Univ Pittsburgh, Ctr Free Radical & Antioxidant Hlth, Pittsburgh, PA 15219 USA

[4] Univ Pittsburgh, Dept Radiat Oncol, Pittsburgh, PA 15260 USA

来源：

FEBS LETTERS | 2009年 / 583卷 / 21期

关键词：

Apoptosis; MnSOD; Irradiation; Preconditioning; ROS; MITOCHONDRIAL RESPIRATORY-CHAIN; ADAPTIVE RESPONSE; REACTIVE OXYGEN; GENE-THERAPY; IONIZING-RADIATION; HYDROGEN-PEROXIDE; HUMAN-LYMPHOCYTES; STRESS; APOPTOSIS; ENZYMES;

D O I：

10.1016/j.febslet.2009.10.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Manganese superoxide dismutase (MnSOD) is vital to the protection of mitochondria and cells against oxidative stress. Earlier, we demonstrated that catalytically active homo-tetramer of MnSOD can be stabilized by oxidative cross-linking. Here we report that this effect may be translated into increased radioresistance of mouse embryonic cells (MECs) by pre-exposure to oxidative stress. Pre-treatment of MECs with antimycin A, rotenone or H2O2 increased their survival after irradiation. Using MnSOD siRNA, we show that MECs with decreased MnSOD levels displayed a lowered ability to preconditioning. Thus oxidative preconditioning may be used for targeted regulation of MnSOD.

引用

页码：3437 / 3442

页数：6

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