PKA, germ cells, and fertility

被引：75

作者：

Burton, Kimberly A. ^{[1
]}

McKnight, G. Stanley ^{[1
]}

机构：

[1] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA

来源：

PHYSIOLOGY | 2007年 / 22卷

关键词：

D O I：

10.1152/physiol.00034.2006

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Temporal and spatial regulation of PKA activity are essential for vigorous sperm motility and for the resumption of meiosis in oocytes, two events required for successful fertilization. Genetic mutations in mice that affect PKA signaling in germ cells lead to infertility and illustrate the importance of this pathway in mammalian reproduction.

引用

页码：40 / 46

页数：7

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